Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
The Mediator Med23 Controls a Transcriptional Switch for Muscle Stem Cell Proliferation and Differentiation in Muscle Regeneration
[Cell Reports] Investigators showed that the Mediator Med23 was critically important for muscle stem cell (MuSC)-mediated muscle regeneration. Med23 was increasingly expressed in activated/proliferating MuSCs on isolated myofibers or in response to muscle injury.
Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease
[Circulation] The authors used smooth muscle cell (SMC) lineage tracing mice and human tissues and applied a range of methods, including molecular, cellular, histological, computational, human genetics, and pharmacological approaches, to investigate the features of SMC-derived cells in atherosclerosis.
LSD1 Inhibition Circumvents Glucocorticoid-Induced Muscle Wasting of Male Mice
[Nature Communications] Researchers showed that glucocorticoid receptor (GR) and the lysine-specific demethylase 1 (LSD1) interact in myofibers of male mice, and that LSD1 connected GR-bound enhancers with NRF1-associated promoters to stimulate target gene expression.
Mechanical Stimulation of Induced Pluripotent Stem Derived Cardiac Fibroblasts
[Scientific Reports] The authors confirmed that iPSC-cardiofibroblasts (CFs) were comparable to primary CFs at gene, protein and functional level. Furthermore, iPSC-derived CFs adopted a pro-fibrotic response to transforming growth factor beta.
Differential Sex-Dependent Susceptibility to Diastolic Dysfunction and Arrhythmia in Cardiomyocytes from Obese Diabetic HFpEF Model
[Cardiovascular Research] Investigators performed echocardiography, electrophysiology, intracellular Ca2+ imaging, and protein analysis. Female heart failure with preserved ejection fraction (HFpEF) mice exhibited more severe diastolic dysfunction.
Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
[American Journal Of Physiology-Cell Physiology] To assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells and isolated mitochondria, researchers performed respiratory and metabolic studies in wildtype and CRISPR-generated GOT2 knockdown C2C12 myocytes.
Neutrophil Extracellular Traps Promote Proliferation of Pulmonary Smooth Muscle Cells Mediated by CCDC25 in Pulmonary Arterial Hypertension
[Respiratory Research] Bioinformatics analysis was employed to screen for potential molecules and mechanisms associated with occurrence and development of pulmonary arterial hypertension.
Low Concentrations of TNF-α In Vitro Transform the Phenotype of Vascular Smooth Muscle Cells and Enhance Their Survival in a Three-Dimensional Culture System
[Artificial Organs] Calf vascular smooth muscle cells were administered tumor necrosis factor-alpha (TNF-α) before culturing in two- and three-dimensional well plates and polyglycolic acid scaffolds.
The Role of Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Atrophy: From Molecular Mechanisms to Therapeutic Insights
[Cellular & Molecular Biology Letters] The authors critically summarize the recent research progress on mitochondrial dynamics and mitophagy in skeletal muscle atrophy, and expound on the intrinsic molecular mechanism of skeletal muscle atrophy caused by mitochondrial dynamics and mitophagy.
Sedentary Behavior in Mice Induces Metabolic Inflexibility by Suppressing Skeletal Muscle Pyruvate Metabolism
[Journal Of Clinical Investigation] Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.
Inhibition of CDK7 Mitigates Doxorubicin Cardiotoxicity and Enhances Anticancer Efficacy
[Cardiovascular Research] Doxorubicin (DOX) exposure induced CDK7 activation in mouse heart and isolated cardiomyocytes. Cardiac-specific ablation of cyclin-dependent kinase 7 (CDK7) attenuated DOX-induced cardiac dysfunction and fibrosis.
Multimodal Cell Atlas of the Aging Human Skeletal Muscle
[Nature] Scientists generated a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
