Volume 5.23 | Jun 29

MUSCN 5.23 | Jun 29
Muscle Cell News by STEMCELL Technologies
Vol. 5.23 – 29 June, 2020
TOP STORY

Muscle and Neuronal Guidepost-Like Cells Facilitate Planarian Visual System Regeneration

Investigators identified a rare subset of muscle cells concentrated at two precise anatomical locations and in tight association with photoreceptor axons.
[Science]

AbstractGraphical Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Variation in RARG Increases Susceptibility to Doxorubicin-Induced Cardiotoxicity in Patient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) from individuals who experienced doxorubicin-induced cardiotoxicity (DIC) showed significantly greater sensitivity to doxorubicin compared to iPSC-CMs from doxorubicin-treated individuals who did not develop DIC in cell viability and optical mapping experiments.
[Scientific Reports]

Full Article

Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation of Phospholamban

The authors showed that KPP regulated cardiomyocyte proteins associated with, but not limited to, apoptosis, muscle contraction, protein turnover, and the respiratory chain.
[Journal of Proteome Research]

Abstract

Pre-Innervated Tissue-Engineered Muscle Promotes a Pro-Regenerative Microenvironment following Volumetric Muscle Loss

Investigators developed pre-innervated tissue-engineered muscle comprised of long aligned networks of spinal motor neurons and skeletal myocytes on aligned nanofibrous scaffolds.
[Communications Biology]

Full Article

Calpain System Is Altered in Survival Motor Neuron-Reduced Cells from In Vitro and In Vivo Spinal Muscular Atrophy Models

Scientists analyzed the level of calpain pathway members in mice and human cellular spinal muscular atrophy models. They indicated an increase of calpain activity in survival motor neuron-reduced motoneurons.
[Cell Death & Disease]

Full Article

Abscisic Acid Enriched Fig Extract Promotes Insulin Sensitivity by Decreasing Systemic Inflammation and Activating LANCL2 in Skeletal Muscle

Abscisic acid (ABA) increased expression of important glycogen synthase, glucose, fatty acid and mitochondrial metabolism genes and increased direct measures of fatty acid oxidation, glucose oxidation and metabolic flexibility in soleus muscle cells from ABA-treated mice with diet-induced obesity.
[Scientific Reports]

Full Article

HDAC1-Mediated Deacetylation of LSD1 Regulates Vascular Calcification by Promoting Autophagy in Chronic Renal Failure

Researchers established the adenine-induced chronic renal failure (CRF) rat model and in vitro vascular calcification (VC) models based on vascular smooth muscle cells to examine histone deacetylase/lysine demethylase 1A/SESN2 as a novel molecular pathway in CRF-induced VC.
[Journal of Cellular and Molecular Medicine]

Full Article

TRPML1 Channels Initiate Ca2+ Sparks in Vascular Smooth Muscle Cells

Scientists investigated the function of transient receptor potential mucolipin 1 (TRPML1) channels in fully differentiated contractile vascular smooth muscle cells.
[Science Signaling]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells
REVIEWS

Coronary Vessel Formation in Development and Disease: Mechanisms and Insights for Therapy

Scientists describe the latest advances in the understanding of the processes involved in coronary vessel formation, with mechanistic insights taken from developmental studies.
[Nature Reviews Cardiology]

Abstract

Metabolic Regulation of Human Pluripotent Stem Cell-Derived Cardiomyocyte Maturation

Further understanding of key metabolic factors driving cardiac maturation will facilitate the generation of more mature human pluripotent stem cell-derived cardiomyocyte models.
[Current Cardiology Reports]

Abstract

INDUSTRY AND POLICY NEWS

PeerWell Partners with CorVel Corporation to Bring Remote Musculoskeletal Recovery to Injured Workers with Cancelled or Postponed Surgery

PeerWell announces a new partnership with comprehensive risk management innovator, CorVel Corporation. Together, CorVel and PeerWell will offer cutting-edge remote care solutions to thousands of injured workers.
[PeerWell]

Press Release

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Editorial

FEATURED EVENT

Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

July 9
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JOB OPPORTUNITIES

Postdoctoral Researcher/Surgery – Muscle Fibrosis

The University of Texas Southwestern Medical Center – Dallas, Texas, United States

Postdoctoral Fellow – Aging Muscle

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

Postdoctoral Position – Muscle Function

Spanish National Center for Cardiovascular Research – Madrid, Spain

Assistant Specialist – Cardiovascular Medicine

University of California, Davis – Davis, California, United States

Postdoctoral Position – Vascular Biology Research

Brigham and Women’s Hospital – Boston, Massachusetts, United States

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