Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Apelin Stimulation of the Vascular Skeletal Muscle Stem Cell Niche Enhances Endogenous Repair in Dystrophic Mice

[Science Translational Medicine] Using chemoinformatic analysis, the authors identified the 13–amino acid form of the peptide hormone apelin as a candidate for systemic stimulation of skeletal muscle endothelial cells.

Amphiphysin-2 (BIN1) Functions and Defects in Cardiac and Skeletal Muscle

[Trends in Molecular Medicine] Investigators discuss the similarities and differences in bridging integrator 1 (BIN1)’s functions in cardiac and skeletal muscle, along with its associated diseases and potential therapies.

A Green Light to Build Muscle Cells on Command

[USC Viterbi School of Engineering] A new major project supported by a Chan Zuckerberg Initiative grant will help bring the technology to shape muscle cells, blood vessels, and nerves into any pattern to fruition, offering revolutionary potential for treating neuromuscular disorders and other diseases.

Deficiency of Heme Oxygenase 1a Causes Detrimental Effects on Cardiac Function

[Journal of Cellular and Molecular Medicine] Investigators generated zebrafish heme oxygenase 1 (HMOX1) mutants using CRISPR/Cas9 genome editing technology. Deletion of hmox1a increased cardiac output and further induced hypertrophy in adults.

Monocarboxylate Transporter 4 Deficiency Enhances High-Intensity Interval Training-Induced Metabolic Adaptations in Skeletal Muscle

[Journal Of Physiology] Researchers developed monocarboxylate transporter 4 knockout mice and confirmed that a lack of MCT4 indeed resulted in pronounced lactate accumulation in skeletal muscle during high-intensity exercise.

Inhibition of CERS1 in Skeletal Muscle Exacerbates Age-Related Muscle Dysfunction

[eLife] Researchers implicated the ceramide synthases (CERS) 1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis of age-related skeletal muscle impairment.

Airway Smooth Muscle and Long-Term Clinical Efficacy following Bronchial Thermoplasty in Severe Asthma

[Thorax] The authors investigated the 2.5-year impact of bronchial thermoplasty on airway smooth muscle mass and clinical parameters by paired data analysis in 22 patients.

Porcine Transient Receptor Potential Channel 1 (TRPC1) Regulates Muscle Growth via the Wnt/β-Catenin and Wnt/Ca2+ Pathways

[International Journal of Biological Macromolecules] Researchers constructed transgenic mice expressing porcine TRPC1 to verify the effects of TRPC1 on skeletal muscle growth and elucidate the underlying mechanism.

Inhibition of miR-25 Ameliorates Cardiac and Skeletal Muscle Dysfunction in Aged mdx/utrn Haploinsufficient (+/-) Mice

[Molecular Therapy - Nucleic Acids] Scientists created a gene transfer using a miR-25 Tough Decoy RNAs inhibitor delivered via recombinant adeno-associated virus serotype 9 to evaluate the effect of miR-25 inhibition on cardiac and skeletal muscle function in aged dystrophin/utrophin haploinsufficient mice mdx/utrn (+/-).

PepGen Receives US FDA Orphan Drug and Rare Pediatric Disease Designations for PGN-EDO51 for the Treatment of Duchenne Muscular Dystrophy

[PepGen Inc.] PepGen Inc. announced that the US FDA granted both orphan drug and rare pediatric disease designations for PGN-EDO51, an investigational therapeutic for Duchenne muscular dystrophy.

The Multifaceted Musculoskeletal Hydatid Disease

[Skeletal Radiology] The authors provide an overview of musculoskeletal hydatid disease and describe its different imaging patterns in soft tissue and bone involvement that should be sought to support the diagnosis.

FoxP1 Represses MEF2A in Striated Muscle

[Molecular and Cellular Biology] A nanobody based affinity-purification/mass spectrometry strategy was employed for a detailed characterization of the MEF2A interactome.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.

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