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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Inhibition of CDK7 Mitigates Doxorubicin Cardiotoxicity and Enhances Anticancer Efficacy
[Cardiovascular Research] Doxorubicin (DOX) exposure induced CDK7 activation in mouse heart and isolated cardiomyocytes. Cardiac-specific ablation of cyclin-dependent kinase 7 (CDK7) attenuated DOX-induced cardiac dysfunction and fibrosis.
Multimodal Cell Atlas of the Aging Human Skeletal Muscle
[Nature] Scientists generated a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels.
Duchenne UK and PPMD Award $500,000 to Evaluate Safety, Tolerability of Muscle Progenitor Cells in Phase I Trial
[Parent Project Muscular Dystrophy] Parent Project Muscular Dystrophy (PPMD) and Duchenne UK announced the recipient of their Joint Call for Therapeutic Projects. Professor Peter Kang MD, from the University of Minnesota Medical School, has been awarded the grant for his research project titled “Phase I clinical trial of myogenic progenitors for DMD.”
LncRNA MIR210HG Promotes Phenotype Switching of Pulmonary Arterial Smooth Muscle Cells through Autophagy-Dependent Ferroptosis Pathway
[Apoptosis] Investigators identified for the first time the potential effect of MIR210HG on disease progression in hypoxic pulmonary hypertension.
Progress of Mitochondrial Function Regulation in Cardiac Regeneration
[Journal Of Cardiovascular Translational Research] The authors review mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models.
Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle
[Journal of Muscle Research and Cell Motility] Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.
KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter
[Journal of Cellular Physiology] The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.
Proximal Telomeric Decompaction Due to Telomere Shortening Drives FOXC1-Dependent Myocardial Senescence
[Nucleic Acids Research] Investigators demonstrated that in heart failure patient cardiomyocytes, telomeres were shortened compared to healthy controls.
HOIL-1L Deficiency Induces Cell Cycle Alteration Which Causes Immaturity of Skeletal Muscle and Cardiomyocytes
[Scientific Reports] The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.
Human Skeletal Muscle Aging Atlas
[Human Skeletal Muscle Aging Atlas] Researchers profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment.
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation
[Circulation] The authors leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte–targeted delivery of reprogramming factors in adult mice to study cardiomyocyte dedifferentiation.
A Versatile High-Throughput Assay Based on 3D Ring-Shaped Cardiac Tissues Generated from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
[eLife] Researchers developed a 96-well plate assay which allowed fast, reproducible, and high-throughput generation of three dimensional cardiac rings around a deformable optically transparent hydrogel pillar of known stiffness.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
