New Drug Shows Promise against Muscle Wasting Disease
A new drug to treat the muscle wasting disease inclusion body myositis (IBM) reverses key symptoms in mice and is safe and well-tolerated in patients. Researchers found that the new drug Arimoclomol reversed the disease’s effects at the cellular level and improved muscle strength in mice. [Press release from University College London discussing online prepublication in Science Translational Medicine] Press Release|Abstract
Effects of Short-Chain Acyl-CoA Dehydrogenase on Cardiomyocyte Apoptosis
Investigators determined the role of short-chain acyl-CoA dehydrogenase (SCAD) in tert-butyl hydroperoxide-induced cardiomyocyte apoptosis. The mRNA and protein expression of SCAD were significantly down-regulated in the cardiomyocyte apoptosis model. [J Cell Mol Med] Full Article
Caveolae Are Involved in Mechanotransduction during Pulmonary Hypertension
Researchers investigated how caveolae are involved in the pathophysiology of pulmonary hypertension (PH) and particularly in mechanotransduction. Pulmonary arterial smooth muscle cells were freshly isolated from control rats and rats suffering from PH induced by three weeks of chronic hypoxia. [Am J Physiol Lung Cell Mol Physiol] Abstract
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INDUSTRY NEWS
Stem Cell Researcher Tracy Grikscheit Awarded $7.1 Million by CIRM
Tracy C. Grikscheit, a principal investigator with USC Stem Cell and The Saban Research Institute of Children’s Hospital Los Angeles, has received a $7.1 million grant from the California Institute of Regenerative Medicine (CIRM) Translational Research program to develop a cellular therapy for the treatment of nerve disorders of the digestive system. [Keck School of Medicine of USC] Press Release
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