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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation
[Circulation] The authors leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte–targeted delivery of reprogramming factors in adult mice to study cardiomyocyte dedifferentiation.
A Versatile High-Throughput Assay Based on 3D Ring-Shaped Cardiac Tissues Generated from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
[eLife] Researchers developed a 96-well plate assay which allowed fast, reproducible, and high-throughput generation of three dimensional cardiac rings around a deformable optically transparent hydrogel pillar of known stiffness.
Thiamine-Modified Metabolic Reprogramming of Human Pluripotent Stem Cell-Derived Cardiomyocyte under Space Microgravity
[Signal Transduction and Targeted Therapy] Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling. Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight, especially thiamine metabolism.
Hypoxia Treatment and Resistance Training Alters microRNA Profiling in Rats Skeletal Muscle
[Scientific Reports] Scientists employed miRNA microarray analysis to investigate the expression profile of miRNAs in skeletal muscle from an animal model of hypoxia-induced muscle atrophy and resistance training aimed at mitigating muscle atrophy.
RSAD2 Is Abundant in Atherosclerotic Plaques and Promotes Interferon-Induced CXCR3-Chemokines in Human Smooth Muscle Cells
[Scientific Reports] The authors harnessed publicly available human carotid atherosclerotic data to explore radical S-adenosyl-L-methionine domain containing 2 (RSAD2) in lesions and employed siRNA-mediated gene-knockdown to investigate its function in interferon gamma-stimulated human aortic smooth muscle cells.
Arterial Smooth Muscle Cell AKAP150 Mediates Exercise-Induced Repression of CaV1.2 Channel Function in Cerebral Arteries of Hypertensive Rats
[Arteriosclerosis Thrombosis And Vascular Biology] Spontaneously hypertensive rats and newly generated smooth muscle–specific AKAP150 knockin mice were used to assess the role of myocyte AKAP150/CaV1.2 channel in regulating cerebral artery function after exercise intervention.
MicroRNA-Mediated Regulation of Muscular Atrophy: Exploring Molecular Pathways and Therapeutics
[Molecular Medicine Reports] The authors lay a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explore other regulatory pathways, such as autophagy and inflammatory signaling.
Eye, Brain Research, and Cardiac Cell Printing Wrap Up Station Week
[NASA Blogs] Advanced space biology continued aboard the International Space Station to develop and test therapies for a range of space-caused and Earthbound health conditions.
NFĸB Signaling Drives Myocardial Injury via CCR2+ Macrophages in a Preclinical Model of Arrhythmogenic Cardiomyopathy
[Journal Of Clinical Investigation] Researchers found that Nuclear factor kappa-B (NFκB) signaling in cardiac myocytes drives myocardial injury, contractile dysfunction, and arrhythmias in Dsg2mut/mut mice. NFκB signaling in cardiac myocytes mobilizes macrophages expressing C-C motif chemokine receptor-2 (CCR2+ cells) to affected areas within the heart, where they mediate myocardial injury and arrhythmias.
Mitolnc Controls Cardiac BCAA Metabolism and Heart Hypertrophy by Allosteric Activation of BCKDH
[Nucleic Acids Research] Investigators described the function of mitolnc in cardiomyocytes, a nuclear encoded long non-coding RNA, located in mitochondria and directly interacting with the branched-chain ketoacid dehydrogenase (BCKDH) complex to increase its activity.
Three-Dimensional Imaging Studies in Mice Identify Cellular Dynamics of Skeletal Muscle Regeneration
[Developmental Cell] Researchers found that myofibers form via two distinct phases of fusion and the residual basement membrane of necrotic myofibers was critical for promoting fusion and orienting regenerated myofibers.
KLF15 Maintains Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Thoracic Aortic Dissection by Interacting with MRTFB
[Journal Of Biological Chemistry] Investigators explored unknown aspects of Krüppel-like factor 15 (KLF15) function. They found that KLF15 expression was reduced in human thoracic aortic dissection (TAD) samples and β-aminopropionitrile monofumarate (BAPN)-induced TAD mouse model.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
