Volume 5.21 | Jun 15

2020-06-15 | MUSCN 5.21
Muscle Cell News by STEMCELL Technologies
Vol. 5.21 – 15 June, 2020
TOP STORY

Autism-Associated SHANK3 Mutations Impair Maturation of Neuromuscular Junctions and Striated Muscles

Scientists found that SHANK3 localized in Z-discs in the skeletal muscle sarcomere and co-immunoprecipitated with α-ACTININ.
[Science Translational Medicine]

Full Article

Guide to everything you need to know about cell separation.
PUBLICATIONSRanked by the impact factor of the journal

Acellular Bioscaffolds Redirect Cardiac Fibroblasts and Promote Functional Tissue Repair in Rodents and Humans with Myocardial Injury

Researchers used acellular biologic extracellular matrix scaffolds (bioscaffolds) to stimulate pathways of muscle repair and restore tissue function. They showed that acellular bioscaffolds with bioinductive properties can redirect cardiac fibroblasts to rebuild microvascular networks and avoid tissue fibrosis.
[Scientific Reports]

Abstract

Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating

Neurons were individually induced, facilitating the regulation of the beating rates of hiPSC-derived cardiomyocytes in an antagonistic manner.
[Scientific Reports]

Full Article

Human Umbilical Cord Blood-Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis.
[Cell Biology and Toxicology]

Abstract

Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-Muscle Myosin II Assembly and Function in Migrating Cells

In cells, phosphorylation of Y155, or its phospho-mimetic mutation, prevented the interaction of regulatory light chain with the myosin heavy chain to form functional non-muscle myosin II units.
[Current Biology]

Full Article

Generation of Myogenic Progenitor Cell-Derived Smooth Muscle Cells for Sphincter Regeneration

Cultivation of myogenic progenitor cells in smooth muscle differentiation medium significantly increased the fraction of alpha smooth muscle actin and smoothelin-positive cells, while leaving the number of desmin-positive cells unchanged.
[Stem Cell Research & Therapy]

Full Article

Kv1.3 Blockade Inhibits Proliferation of Vascular Smooth Muscle Cells In Vitro and Intimal Hyperplasia In Vivo

In vitro phenotypic modulation of vascular smooth muscle cells (VSMC) was associated to an increased functional expression of Kv1.3 channels, and only selective Kv1.3 channel blockers were able to inhibit porcine VSMC proliferation.
[Translational Research]

Abstract

IGFBP6 Regulates Vascular Smooth Muscle Cell Proliferation and Morphology via Cyclin E-CDK2

Knocking down insulin‐like growth factor binding protein 6 in vascular smooth muscle cells significantly attenuated cell proliferation and induced the S phase arrest during the cell cycle.
[Journal of Cellular Physiology]

Abstract

Advanced Glycation End-Products Suppress Autophagy by AMPK/mTOR Signaling Pathway to Promote Vascular Calcification

Pretreatment with autophagy activator rapamycin and AMPK activator AICAR both upregulated the autophagy level and downregulated the effects of advanced glycation end-products on osteoblastic differentiation of vascular smooth muscle cells.
[Molecular and Cellular Biochemistry]

Abstract

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REVIEWS

The Role of B Cells in Heart Failure and Implications for Future Immunomodulatory Treatment Strategies

B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.
[ESC Heart Failure]

Full Article

INDUSTRY AND POLICY NEWS

Sarepta Therapeutics Announces Positive Expression and Functional Data From the SRP-9003 Gene Therapy Trial to Treat Limb-Girdle Muscular Dystrophy Type 2E

Sarepta Therapeutics announced positive results from a study of SRP-9003, its investigational gene therapy for limb-girdle muscular dystrophy Type 2E.
[Sarepta Therapeutics]

Press Release

FDA Just Gave a Thumbs Down to Trump’s Favorite COVID-19 Drugs

The FDA revoked its emergency use authorization for hydroxychloroquine sulfate and chloroquine phosphate to treat COVID-19.
[ScienceInsider]

Editorial

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]

Editorial

FEATURED EVENT

American Association for Cancer Research (AACR) Annual Meeting 2020 – Virtual Meeting II

2020-06-22 – 2020-06-24 
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Associate – Cancer Research

University of Miami Health System – Miami, United States

Postdoctoral Position – Vascular Biology Research

Brigham and Women’s Hospital – Boston, Massachusetts, United States

Postdoctoral Studentship – Cancer Biology

Berlin School of Integrative Oncology – Berlin, Germany

Assistant Specialist – Cardiovascular Medicine

University of California, Davis – Davis, California, United States

Postdoctoral Position – Muscle Function

Spanish National Center for Cardiovascular Research – Madrid, Spain

Postdoctoral Position – Tissue Engineering

Stanford University School of Medicine – Stanford, California, United States

Postdoctoral Fellow – Aging Muscle

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

> See All Jobs

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