Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Porcine Transient Receptor Potential Channel 1 (TRPC1) Regulates Muscle Growth via the Wnt/β-Catenin and Wnt/Ca2+ Pathways

[International Journal of Biological Macromolecules] Researchers constructed transgenic mice expressing porcine TRPC1 to verify the effects of TRPC1 on skeletal muscle growth and elucidate the underlying mechanism.

Inhibition of miR-25 Ameliorates Cardiac and Skeletal Muscle Dysfunction in Aged mdx/utrn Haploinsufficient (+/-) Mice

[Molecular Therapy - Nucleic Acids] Scientists created a gene transfer using a miR-25 Tough Decoy RNAs inhibitor delivered via recombinant adeno-associated virus serotype 9 to evaluate the effect of miR-25 inhibition on cardiac and skeletal muscle function in aged dystrophin/utrophin haploinsufficient mice mdx/utrn (+/-).

PepGen Receives US FDA Orphan Drug and Rare Pediatric Disease Designations for PGN-EDO51 for the Treatment of Duchenne Muscular Dystrophy

[PepGen Inc.] PepGen Inc. announced that the US FDA granted both orphan drug and rare pediatric disease designations for PGN-EDO51, an investigational therapeutic for Duchenne muscular dystrophy.

The Multifaceted Musculoskeletal Hydatid Disease

[Skeletal Radiology] The authors provide an overview of musculoskeletal hydatid disease and describe its different imaging patterns in soft tissue and bone involvement that should be sought to support the diagnosis.

FoxP1 Represses MEF2A in Striated Muscle

[Molecular and Cellular Biology] A nanobody based affinity-purification/mass spectrometry strategy was employed for a detailed characterization of the MEF2A interactome.

FAK Mediates Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation by Modulating Mitochondrial Transcription Termination Factor 1/Cyclin D1

[Cts-Clinical And Translational Science] Scientists investigated the mechanism of focal adhesion kinase (FAK)-dependent hypoxia-induced proliferation on human pulmonary artery smooth muscle cells.

Macrod1 Suppresses Diabetic Cardiomyopathy via Regulating PARP1-NAD+-SIRT3 Pathway

[Acta Pharmacologica Sinica] A mice model was established by feeding a high-fat diet and intraperitoneal injection of streptozotocin. Scientists showed that Macrod1 expression levels were significantly downregulated in cardiac tissue of diabetic cardiomyopathy mice.

Spatially Organized Cellular Communities Form the Developing Human Heart

[Nature] The authors integrated single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization to resolve the identity of the cardiac cell types that develop the human heart.

Engineering a Heart Conduit: New $2M NIH Grant for Yale Research

[Yale School of Medicine] The National Institutes of Health (NIH) recently awarded Dr. Yibing Qyang, an associate professor of medicine and associate professor of biomedical engineering, and his colleagues in his laboratory a $2+ million R01 grant to support research to create an artificial blood vessel that can grow, pump, and resist infection and clotting.

Activation of the IKK2-NF B Pathway in VSMCs Inhibits Calcified Vascular Stiffness in CKD

[JCI Insight] Researchers found that CKD induced inflammatory pathways through the local activation of the IKK2-NF B pathway in vascular smooth muscle cells associated with calcified vascular stiffness.

Sex-Specific Epigenetics Drive Low GPER Expression in Gastrointestinal Smooth Muscles in Type 2 Diabetic Mice

[Scientific Reports] The authors explored sexually differentiated GPER expression and gastrointestinal symptoms related to G-protein coupled estrogen receptor (GPER) alterations in wild-type and T2D mice.

Smooth Muscle Cell-Specific MMP-3 Deletion Reduces Osteogenic Transformation and Medial Artery Calcification

[Cardiovascular Research] Investigators found that matrix metalloproteinase 3 (MMP-3) was increased in rodent models of medial calcification as well as in vascular smooth muscle cells cultured in a phosphate calcification medium.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.

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