Volume 1.09 | May 9

Muscle Cell News 1.09 May 9, 2016
Muscle Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  MUSCN on Twitter
Cardiologists Discover New Mechanism for Pathogenesis of Heart Failure
Researchers discovered a previously unknown heart muscle protein and also described a new mechanism by which heart failure can develop. They showed that “Myoscape” binds to a specific calcium channel on the heart muscle and thus has a significant effect on its function. [Press release from Kiel’s Christian Albrecht University discussing online prepublication in Nature Communications] Press Release | Full Article
Learn more about our cell attachment substrates and matrices for pluripotent stem cell research.
PUBLICATIONS (Ranked by impact factor of the journal)

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice
Scientists studied the effect of cardiac fibroblast (CF) ablation on cardiac remodeling. They characterized subgroups of murine CF by single cell expression analysis and identified periostin as the marker showing the highest correlation to an activated CF phenotype. [Circ Res] Abstract

Dual Effects of VEGF-B on Activating Cardiomyocytes and Cardiac Stem Cells to Protect the Heart against Short- and Long-Term Ischemia–Reperfusion Injury
Researchers investigated whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion heart and promotes CSC mobilization and angiogenesis. [J Transl Med] Full Article

Molecular Profiling of Dilated Cardiomyopathy That Progresses to Heart Failure
Investigators performed RNA-seq at different stages of disease to define molecular signaling in the progression from pre-dilated cardiomyopathy (DCM) hearts to DCM and overt heart failure using a genetic model of DCM. [JCI Insight] Full Article | Press Release


Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy
Researchers examined synaptic function in three well-studied spinal and bulbar muscular atrophy mouse models—the AR97Q, knock-in, and myogenic141 models—by recording in vitro miniature and evoked end-plate potentials intracellularly from adult muscle fibers. [J Neurosci] Abstract | Press Release

Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors
Scientists showed that Pax7 levels are maintained in proliferating muscle progenitors by a mechanism involving casein kinase 2-dependent Pax7 phosphorylation at S201. Point mutations preventing S201 phosphorylation or casein kinase 2 inhibition result in decreased Pax7 protein in proliferating muscle progenitors. [PLoS One] Full Article


Curcumin Exerts Its Anti-Hypertensive Effect by Down-Regulating the AT1 Receptor in Vascular Smooth Muscle Cells
Scientists examined how curcumin regulates AT1 receptor expression in vascular smooth muscle cells and investigated the physiological significance of this regulation in angiotensin II-induced hypertension. [Sci Rep] Full Article

Microstructured Human Fibroblast-Derived Extracellular Matrix Scaffold for Vascular Media Fabrication
Scaffolds were seeded with smooth muscle cells. These cells elongated and migrated in a single direction, following a specific angle relative to the direction of the aligned fibroblastic extracellular matrix. [J Tissue Eng Regen Med] Abstract

Rosuvastatin Attenuates CD40L-Induced Downregulation of Extracellular Matrix Production in Human Aortic Smooth Muscle Cells via TRAF6-JNK-NF-κB Pathway
CD40L suppressed prolyl-4-hydroxylase α1 expression in human aortic smooth muscle cells in a dose- and time-dependent manner, with insignificant changes in MMP2 expression and negative enzymatic activity of MMP9. [PLoS One] Full Article

Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
Cardiac Gene Therapy: Are We There Yet?
The authors summarize gene delivery carriers, modes of delivery, recent preclinical/clinical studies and potential therapeutic targets in cardiovascular disease. [Gene Ther] Abstract

Visit our reviews page to see a complete list of reviews in the muscle cell research field.
BEAT BioTherapeutics Announces Scientific Presentation
BEAT BioTherapeutics Corporation announced that co-founder and Scientific Advisory Board member Dr. Michael Regnier presented “AAV6-Mediated Cardiac-Specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility via Myosin Activation.” [Press release from BEAT BioTherapeutics (Business Wire) discussing research presented at the 19th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC] Press Release

Follistatin Gene Therapy Increases Function in Inclusion Body Myositis Patients
Milo Biotechnology described promising safety and initial efficacy data in sporadic inclusion body myositis (sIBM) patients treated with follistatin gene therapy. In total, nine sIBM patients received follistatin gene therapy treatments and have been followed up to four years. [Press release from Milo Biotechnology discussing research presented at the 19th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC] Press Release

Processed Fat Cells Show Potential as Treatment for Refractory Ischemia Patients
Patients treated with processed autologous adipose-derived regenerative cells injected into the heart muscle demonstrated symptomatic improvement and a trend towards lower rates of heart failure hospitalizations and angina, despite no improvement in left ventricle ejection fraction or ventricular volumes. [Press release from the Society for Cardiovascular Angiography and Interventions (SCAI) discussing research presented at the SCAI 2016 Scientific Sessions, Orlando] Press Release

Utah Study Finds Improvements in Warfarin Use for Atrial Fibrillation Treatment Necessary to Protect Kidney Function and Heart Health
Atrial fibrillation patients taking Warfarin, a popular blood-thinning drug, are at higher risk of developing kidney failure if anticoagulation levels are not properly managed, according to a new study from researchers at the Intermountain Medical Center Heart Institute. [Press release from the Intermountain Medical Center Heart Institute discussing research presented at the Heart Rhythm Society’s 37th Annual Scientific Sessions, San Francisco] Press Release

New Study Finds Patients with Atrial Fibrillation Who Are Treated with Common Blood Thinner Have Higher Rates of Dementia
A new study by researchers at the Intermountain Medical Center Heart Institute of more than 10,000 patients treated long term with the blood thinner, Warfarin, revealed higher rates of dementia for patients with atrial fibrillation versus patients without the common heart rhythm disorder. [Press release from the Intermountain Medical Center Heart Institute discussing research presented at the Heart Rhythm Society’s 37th Annual Scientific Sessions, San Francisco] Press Release

Study Finds Cardiac Ablation Doesn’t Reduce Atrial Fibrillation Risk for Patients with Syndrome
Patients with Wolff-Parkinson-White syndrome who receive catheter ablation to cure their abnormal heart rhythms are just as likely as non-ablated patients to develop atrial fibrillation no matter what age they receive ablation, according to a new study. [Press release from the Intermountain Medical Center Heart Institute discussing research presented at the Heart Rhythm Society’s 37th Annual Scientific Sessions, San Francisco] Press Release

New wallchart from our sponsor:
Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration).
Request your free copy.
Ligand Acquires Portfolio of Synthetic Royalty and Milestone Rights from CorMatrix® Cardiovascular for $17.5 Million
Ligand Pharmaceuticals Incorporated announced the acquisition of economic rights to multiple programs owned by CorMatrix®. Ligand will pay $17.5 million and in return will receive a portion of revenue from CorMatrix’s existing marketed products and will have the right to receive future synthetic royalties from potential future products. [Ligand Pharmaceuticals Incorporated] Press Release

Axiogenesis Secures Major Funding for Its Expansion Course
Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand product development, strengthen its disease modeling capabilities and increase market presence. Axiogenesis’ current product portfolio includes several validated induced pluripotent stem cell derived cardiac and neural cell types. [Axiogenesis AG (PR Newswire Association LLC)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 45th European Muscle Conference
September 2-6, 2016
Montpellier, France

Visit our events page to see a complete list of events in the muscle cell community.
NEW Postdoctoral Scientist – Airway Smooth Muscle Biology (UCSF)

NEW Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University)

Research Technologist – Myogenic and Progenitor Cell (STEMCELL Technologies Inc.)

Postdoctoral Position – Chemical and Structural Biology of RNA (The Scripps Research Institute)

PhD Positions – Molecular and Cellular Biology (IGBMC)

Research Technician – Myogenesis, Neurogenesis and Related Diseases (Fred Hutchinson Cancer Research Center)

PhD Position – Muscle Fiber Type Switch in Congenital Myopathies (King’s College London)

Postdoctoral Fellow – Pathogenesis of Heart and Vascular Injury (University of Alberta)

Postdoctoral Researcher – Stem Cell Biology Regenerative Medicine (NUI Galway)

Research Assistant – Skeletal Muscle Cell Biology (Nestlé)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Muscle Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Muscle Cell News: Archives | Events | Contact Us