Volume 1.01 | Mar 14

Muscle Cell News 1.01 March 14, 2016
Muscle Cell News
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‘Person-On-A-Chip’ — Engineers Create Lab-Grown Heart and Liver Tissue for Drug Testing and More
Scientists have developed a new way of growing realistic human tissues outside the body. Using the platform, the team has built model versions of both heart and liver tissues that function like the real thing. [Press release from the University of Toronto discussing online publication in Nature Materials] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Myocardial Pathology Induced by Aldosterone Is Dependent on Non-Canonical Activities of G Protein-Coupled Receptor Kinases
Researchers showed that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardial signaling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death activity and GRK5 pro-hypertrophic action. Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk with the angiotensin II type-1 receptor. [Nat Commun] Full Article | Press Release

Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue
Investigators sought to incorporate a patterned microvasculature into engineered heart tissue, which balances the competing demands from cardiomyocytes to contract the matrix versus the vascular lumens that need structural support. [Tissue Eng Part A] Abstract

Epigenetic and lncRNA Regulation of Cardiac Pathophysiology
The authors provide an insight into the pathogenesis of heart failure in adults. Their studies reveal a mechanistic link between fetal cardiomyocytes and pathologically stressed adult cardiomyocytes at the level of chromatin regulation. [Biochim Biophys Acta] Abstract


A Branched-Chain Amino Acid Metabolite Drives Vascular Fatty Acid Transport and Causes Insulin Resistance
Researchers found that 3-hydroxyisobutyrate is secreted from muscle cells, activates endothelial fatty acid transport, stimulates muscle fatty acid uptake in vivo and promotes lipid accumulation in muscle, leading to insulin resistance in mice. [Nat Med] Abstract | Press Release

Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice
To examine the functional ramifications associated with greater Cathepsin S (Ctss) expression, the Ctss gene was deleted in the mdx genetic background, resulting in protection from muscular dystrophy pathogenesis that included reduced myofiber turnover and histopathology, reduced fibrosis and improved running capacity. [J Biol Chem] Abstract | Full Article

The Different Fate of Satellite Cells on Conductive Composite Electrospun Nanofibers with Graphene and Graphene Oxide Nanosheets
Muscle satellite cells enriched by a pre-plating technique were cultured in fabricated membranes and their proliferation and differentiation behavior studied by MTT, Real-Time PCR assays and 4′, 6-diamidino-2-phenylindole staining. [Biomed Mater] Abstract

In Vitro Effects of 1α,25(OH)2D3-Glycosides from Solbone A (Solanum glaucophyllum Leaves Extract; Herbonis AG) Compared to Synthetic 1α,25(OH)2D3 on Myogenesis
Scientists evaluated the role 1α,25(OH)2D3-glycosides enriched natural product Solbone A from S. glaucophyllum leaf extract compared with synthetic 1α,25(OH)2D3 on myogenic differentiation in C2C12 myoblasts. [Steroids] Abstract


Tissue-Specific Cultured Human Pericytes: Perivascular Cells from Smooth Muscle Tissue Have Restricted Mesodermal Differentiation Ability
Researchers investigated the differentiation potentials of isogenic human cultured pericytes (hPCs) isolated from skeletal (sk-hPCs) and smooth muscle tissues (sm-hPCs). They found that both sk-hPCs and sm-hPCs expressed known pericytic markers and did not express endothelial, hematopoietic and myogenic markers. Both sk-hPCs and sm-hPCs were able to differentiate into smooth muscle cells. [Stem Cells Dev] Abstract

Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of β1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation
The putative role of β1 integrin subunit alterations due to shedding in airway smooth muscle (ASM) in an allergic asthma model was evaluated. Various polypeptides with similar molecular weights were detected with both the cytosolic and extracellular β1 integrin subunit antibodies in isolated airway myocytes and the connective tissue that surrounds the ASM bundle. [J Cell Biochem] Abstract

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Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration, Aging and Disease
It has become apparent that satellite cell fate during muscle regeneration and ageing, and in the context of Duchenne muscular dystrophy, is governed by an intricate network of intrinsic and extrinsic regulators. Targeted manipulation of this network may offer unique opportunities for muscle regenerative medicine. [Nat Rev Mol Cell Biol] Abstract

Crosstalk between the Heart and Peripheral Organs in Heart Failure
The authors review mechanisms regulating myocardial inflammation in HF and the role of factors secreted by the heart in communication with peripheral tissues. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the muscle cell research field.
Temple University Hospital Offering New Trial Using Donor Stem Cells to Treat Heart Failure
Temple University Hospital is participating in a nationwide, Phase III clinical trial investigating stem cells as a treatment for patients with chronic heart failure due to left ventricular systolic dysfunction. The trial, dubbed DREAM-HF, is a double-blind, randomized, placebo controlled trial investigating whether donor stem cells which are injected into the damaged portion of the heart can restore heart muscle function. [Temple University] Press Release

Sarepta Says Yet to Receive New Date for Panel Review of Muscle Wasting Drug
Sarepta Therapeutics Inc. said it had not received a rescheduled date for the review of its drug for a rare muscle wasting disorder by an FDA advisory panel and would slash about 17 percent of its workforce. FDA staff said they were unconvinced about the effectiveness of the drug, which is designed to treat a subset of patients with Duchenne muscular dystrophy. [Reuters] Press Release

Barry Coller Receives the 2016 Gill Award for Outstanding Contributions to Cardiovascular Research
Barry Coller, vice president for medical affairs and physician-in-chief of The Rockefeller University Hospital, has won the 2016 Gill Award. The prize, given by the University of Kentucky Gill Heart Institute, recognizes lifelong achievements in the study of cardiovascular biology and disease. [The Rockefeller University] Press Release

Vericel Announces Positive Top-Line Results from Phase IIb ixCELL-DCM Clinical Trial of Ixmyelocel-T in Patients with Heart Failure Due to Ischemic Dilated Cardiomyopathy
Vericel Corporation announced top-line results from the company’s Phase IIb ixCELL-DCM clinical trial of ixmyelocel-T in patients with advanced heart failure due to ischemic dilated cardiomyopathy (DCM). [Vericel Corporation] Press Release

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NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the muscle cell community.
NEW Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

NEW Researcher – Striated Muscle in Health and Disease (Linnaeus University)

Postdoctoral Researcher – Cell Biology and Regenerative Therapies in Cardiovascular Diseases (Universitätsmedizin Goettingen)

Postdoctoral Positions – Human Stem Cells and Heart Regenerative Medicine (University of Pittsburgh)

Postdoctoral Fellow – Pulmonary Vascular Cell and Molecular Biology (Massachusetts General Hospital)

Postdoctoral Fellow – Cardiovascular and Metabolic Disease (AstraZeneca)

Postdoctoral Fellow – Biomedical Science (Linnaeus University)

Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa)

Postdoctoral Fellow – Neurology Research in Cerebral Small Vessel Diseases (The Chinese University of Hong Kong)

PhD Studentship – Functional Genomics of Muscle, Nerve and Brain Disorders (Leids University Medical Center)

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