Volume 1.00 | Mar 7

Muscle Cell News 1.00 March 7, 2016
Muscle Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
New Method for Producing Heart Cells May Hold the Key to Treating Heart Failure
Scientists have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease. [Press release from the Gladstone Institutes discussing online publication in Cell Stem Cell] Press Release | Full Article | Graphical Abstract
Download Mini-Review: Myogenic Progenitor and Satellite Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
CARDIAC MUSCLE CELLS

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming
Scientists screened for epigenetic regulators of induced cardiomyocyte (iCM) reprogramming and found that reducing levels of the polycomb complex gene Bmi1 significantly enhanced induction of beating iCMs from neonatal and adult mouse fibroblasts. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release

Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming with Cardiosphere-Derived Extracellular Membrane Vesicles
Researchers sought to investigate the effect of cardiosphere-derived extracellular membrane vesicles (CSp-EMVs) on fibroblasts in vitro and tested whether priming with CSp-EMVs could confer salutary properties on fibroblasts in vivo. [J Am Coll Cardiol] Abstract | Press Release

Rationally Engineered Troponin C Modulates In Vivo Cardiac Function and Performance in Health and Disease
Investigators developed a protein engineering approach to directly tune in vivo cardiac contractility by tailoring the ability of the heart to respond to the Ca2+ signal. In a myocardial infarction (MI) model of heart failure, expression of Ca2+-sensitizing Troponin C before the MI preserved cardiac function and performance. [Nat Commun] Full Article | Press Release

Influence of Aging on the Quantity and Quality of Human Cardiac Stem Cells
Scientists examined whether aging affected the quantity and quality of cardiac stem cells using cells obtained from 26 patients of various ages. They investigated growth rate, senescence, DNA damage, and the growth factor production of cardiosphere-derived cells. [Sci Rep] Full Article

Systemic Injection of AAV9 Carrying a Periostin Promoter Targets Gene Expression to a Myofibroblast-Like Lineage in Mouse Hearts after Reperfused Myocardial Infarction
Scientists constructed expression cassettes using a modified periostin promoter to drive gene expression in a cardiac myofibroblast-like lineage, with only occasional spillover into cardiomyocyte-like cells. [Gene Ther] Abstract

SKELETAL MUSCLE CELLS

Nfix Regulates Temporal Progression of Muscle Regeneration through Modulation of Myostatin Expression
Investigators previously showed a pivotal role for Nfix in regulating the transcriptional switch from embryonic to fetal myogenesis. In this study, they showed that Nfix directly represses the Myostatin promoter, thus controlling the proper timing of satellite cell differentiation and muscle regeneration. [Cell Rep]
Full Article | Graphical Abstract

KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling
The authors report that KLF7 functioned as a key mediator involved in low-level TGF-β signaling and canonical Notch signaling-induced satellite cell (SC) quiescence and myoblast arrest. The data obtained showed that KLF7 was upregulated in quiescent SCs and non-proliferating myoblasts. [Stem Cells] Abstract

Induction of CCAAT/Enhancer-Binding Protein β Expression with the Phosphodiesterase Inhibitor Isobutylmethylxanthine Improves Myoblast Engraftment into Dystrophic Muscle
Scientists demonstrated that induction of the transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) using the cyclic adenosine monophosphate phosphodiesterase inhibitor isobutylmethylxanthine (IBMX) results in enhanced myoblast expansion in culture and increased satellite cell marker expression. [Stem Cells Transl Med] Abstract

Tumor Necrosis Factor-α Impairs Adiponectin Signaling, Mitochondrial Biogenesis and Myogenesis in Primary Human Myotubes Cultures
Researchers aimed to examine the impact of adiponectin receptor 1 deficiency and TNF-α treatment on adiponectin signaling, proliferative capacity, myogenic differentiation and mitochondrial biogenesis in primary human skeletal muscle cells. [Am J Physiol Heart Circ Physiol] Abstract

SMOOTH MUSCLE CELLS

Nuclear PTEN Functions as an Essential Regulator of SRF-Dependent Transcription to Control Smooth Muscle Differentiation
Scientists report that the lipid and protein phosphatase, PTEN, has a novel role in the nucleus by functioning as an indispensable regulator with serum response factor (SRF) to maintain the differentiated smooth muscle phenotype. [Nat Commun] Full Article

Hyperinsulinemia Adversely Affects Lung Structure and Function
Scientists demonstrated that insulin can adversely affect respiratory health. Insulin treatment significantly increased the proliferation of primary human airway smooth muscle cells and induced collagen release. [Am J Physiol Lung Cell Mol Physiol] Abstract

Watch Video MesenTrek Rise of Enriched Mouse MSC Cultures
 
REVIEWS
Regenerative Decline of Stem Cells in Sarcopenia
The authors review the most recent findings on the causes underlying satellite cell functional decline with aging, and discuss the prevalent view whereby age-associated extrinsic factor alterations impact negatively on satellite cell-intrinsic mechanisms, resulting in deficient muscle regeneration with aging. [Mol Aspects Med] Abstract

Visit our reviews page to see a complete list of reviews in the muscle cell research field.
 
SCIENCE NEWS
Gene Identified that Helps Wound Healing
Researchers at Ohio State University have pinpointed a human gene product that helps to regulate wound healing and may control scarring in people recovering from severe injuries and damage to certain internal organs. [Press release from the Biophysical Society (EurekAlert!) discussing research presented at the 60th Annual Meeting of the Biophysical Society, Los Angeles] Press Release | Abstract

BioCardia®, Inc. Announces Two Presentations Related to CardiAMP Cell Therapy
BioCardia®, Inc. announced two presentations related to CardiAMP cell therapy. Dr. Martin W. Bergmann presented the clinical results of the ALSTER HELIX Phase I study. [Press release from BioCardia®, Inc. discussing research presented at the Cardiovascular Research Technologies (CRT) 2016 Meeting, Washington D.C.] Press Release

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INDUSTRY NEWS
Capricor Therapeutics Announces the First Patient with Duchenne Muscular Dystrophy-Related Cardiomyopathy Treated with CAP-1002 in the HOPE-Duchenne Phase I/II Clinical Trial
Capricor Therapeutics, Inc. announced continuing enrollment of, and the treatment of the first patient with Duchenne Muscular Dystrophy-related cardiomyopathy with CAP-1002 in the HOPE-Duchenne Phase I/II clinical trial. [Capricor Therapeutics, Inc.] Press Release

Creative Medical Health Inc. Announces Creation of AngioStem Inc. Subsidiary to Commercialize Issued Cardiovascular Stem Cell Patent
Creative Medical Health announced formation of a subsidiary company, AngioStem Inc., dedicated to commercialization of its cardiovascular assets, including issued US patent #9,205,112, titled “Combination Therapy of Cardiovascular Disease.” [Creative Medical Health, Inc. (Business Wire)] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposia – Cardiac Development, Regeneration and Repair
April 3-7, 2016
Snowbird, United States

Visit our events page to see a complete list of events in the muscle cell community.
 
JOB OPPORTUNITIES
Assistant or Associate Professor – Cardiovascular Research (Baylor College of Medicine)

Postdoctoral Researcher – Cell Biology and Regenerative Therapies in Cardiovascular Diseases (Universitätsmedizin Goettingen)

Postdoctoral Positions – Human Stem Cells and Heart Regenerative Medicine (University of Pittsburgh)

Postdoctoral Fellow – Physiological Regulation of Arterial Smooth Muscle Cell Ion Channels (University of Tennessee)

Postdoctoral Fellow – Pulmonary Vascular Cell and Molecular Biology (Massachusetts General Hospital)

Postdoctoral Fellow – Cardiovascular and Metabolic Disease (AstraZeneca)

Postdoctoral Fellow – Biomedical Science (Linnaeus University)

Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa)

Postdoctoral Fellow – Neurology Research in Cerebral Small Vessel Diseases (The Chinese University of Hong Kong)

PhD Studentship – Functional Genomics of Muscle, Nerve and Brain Disorders (Leids University Medical Center)


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