MUSCN 5.22 | Jun 22

Muscle Cell News 5.22 | Jun 22
Muscle Cell News by STEMCELL Technologies
Vol. 5.22 – 22 June, 2020
TOP STORY

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification

In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
[Circulation Research]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]

Abstract

FOXO3a-Mediated Long Non-Coding RNA LINC00261 Resists Cardiomyocyte Hypoxia/Reoxygenation Injury via Targeting miR23b-3p/NRF2 Axis

The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cells. Overexpression of LINC00261 improved cardiac function and reduced myocardium apoptosis.
[Journal of Cellular and Molecular Medicine]

Full Article

Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

Researchers present a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]

AbstractGraphical Abstract

Yin Yang 1 Is Required for PHD Finger Protein 20-Mediated Myogenic Differentiation In Vitro and In Vivo

Investigators found that protein and mRNA expression levels of PHD finger protein 20 (PHF20) were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation]

Abstract

Dissecting Myogenin-Mediated Retinoid X Receptor Signaling in Myogenic Differentiation

The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
[Communications Biology]

Full Article

The Importance of the ZBED6-IGF2 Axis for Metabolic Regulation in Mouse Myoblast Cells

Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal]

Full Article

Clonally Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping Efferocytosis and Activating the Complement Cascade

Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Searching for Novel Hydrogen Sulfide Donors: The Vascular Effects of Two Thiourea Derivatives

In human aortic smooth muscle cells, diphenylthiourea caused membrane hyperpolarization, mediated by activation of KATP and Kv7 potassium channels.
[Pharmacological Research]

AbstractGraphical Abstract

LncRNA LBX2-AS1 Facilitates Abdominal Aortic Aneurysm through miR-4685-5p/LBX2 Feedback Loop

The effects of dysregulated ladybird homeobox 2 antisense RNA 1 or ladybird homeobox 2 on vascular smooth muscle cell biological processes were surveyed via cell counting kit-8, methyl thiazolyl tetrazolium, terminal-deoxynucleoitidyl transferase mediated nick end labeling and caspase-3 activity assays.
[Biomedicine & PharmacoTherapy]

Full Article

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REVIEWS

Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target

The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]

Abstract

INDUSTRY AND POLICY NEWS

Sarepta Therapeutics and Selecta Biosciences Enter Into Research License and Option Agreement for Selecta’s ImmTOR Immune Tolerance Platform in Neuromuscular Diseases

Sarepta Therapeutics, Inc. and Selecta Biosciences, Inc. announced that they have entered into a research license and option agreement granting Sarepta an option to license the rights to develop and commercialize Selecta’s immune tolerance platform for use in Duchenne muscular dystrophy and certain limb-girdle muscular dystrophies.
[Sarepta Therapeutics, Inc.]

Press Release

Sarepta Therapeutics and Codiak BioSciences Collaborate to Research and Develop Exosome-Based Therapeutics for Rare Diseases

Sarepta Therapeutics, Inc. and Codiak BioSciences, Inc. announced a global research and option agreement to design and develop engineered exosome therapeutics to deliver gene therapy, gene editing and RNA technologies for neuromuscular diseases.
[Sarepta Therapeutics, Inc.]

Press Release

US Science Groups Wary of New Senate Bills to Curb Foreign Influences

A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider]

Editorial

FEATURED EVENT

Tissue Plasticity: Preservation and Alteration of Cellular Identity

2020-10-04 – 2020-10-07
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

Northwestern University – Chicago, Illinois, United States

Postdoctoral Associate – Cancer Research

University of Miami Health System – Miami, United States

Postdoctoral Position – Vascular Biology Research

Brigham and Women’s Hospital – Boston, Massachusetts, United States

Postdoctoral Studentship – Cancer Biology

Berlin School of Integrative Oncology – Berlin, Germany

Assistant Specialist – Cardiovascular Medicine

University of California, Davis – Davis, California, United States

Postdoctoral Position – Tissue Engineering

Stanford University School of Medicine – Stanford, California, United States

Postdoctoral Position – Muscle Function

Spanish National Center for Cardiovascular Research – Madrid, Spain

Postdoctoral Fellow – Aging Muscle

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

> See All Jobs

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