Volume 5.24 | Jul 6

MUSCN 5.24 | Jul 6
Muscle Cell News by STEMCELL Technologies
Vol. 5.24 – 06 July, 2020
TOP STORY

Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

Primary adult rat ventricular myocytes were studied for morphology and intracellular signaling. Cardiac myocyte-specific CIP4 gene deletion in mice attenuated pressure overload-induced pathological cardiac remodeling and heart failure.
[Circulation]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Intrinsic Color Sensing System Allows for Real-Time Observable Functional Changes on Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Scientists developed an intrinsic color sensing system utilizing a microgroove structural color methacrylated gelatin film, which allowed them to monitor the cardiac differentiation process of hiPSC-derived cardiac progenitor cells in real time.
[ACS Nano]

Abstract

Induced Pluripotent Stem Cells of Patients with Tetralogy of Fallot Reveal Transcriptional Alterations in Cardiomyocyte Differentiation

Induced pluripotent stem cells were generated and further differentiated to cardiomyocytes using standard methods from two well-characterized Tetralogy of Fallot patients and their healthy relatives serving as controls.
[Scientific Reports]

Full Article

Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection

Investigators utilized human induced pluripotent stem cell-derived cardiomyocytes as a model to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2.
[Cell Reports Medicine]

AbstractFull ArticleGraphical Abstract

GJA1-20k Attenuates Ang II-Induced Pathological Cardiac Hypertrophy by Regulating Gap Junction Formation and Mitochondrial Function

In neonatal rat cardiomyocytes, overexpression of GJA1-20k attenuated Ang II-induced cardiomyocyte hypertrophy and caused elevated levels of gap junction coupling at the cell-cell borders.
[Acta Pharmacologica Sinica]

Abstract

Irradiation Dependent Inflammatory Response May Enhance Satellite Cell Engraftment

Scientists found no difference in the percentage of dying cells in immunodeficient dystrophic mouse muscles at the times after the irradiation dose that enhanced donor cell engraftment.
[Scientific Reports]

Full Article

A Reference Single-Cell Transcriptomic Atlas of Human Skeletal Muscle Tissue Reveals Bifurcated Muscle Stem Cell Populations

Differential expression analysis identified transcriptional profiles altered in the activated muscle stem/progenitor cells including genes associated with aging, obesity, diabetes, and impaired muscle regeneration, as well as long non-coding RNAs previously undescribed in human myogenic cells.
[Skeletal Muscle]

Full Article

Novel Airway Smooth Muscle-Mast Cell Interactions and a Role for the TRPV4-ATP Axis in Non-Atopic Asthma

Trypsin was shown to evoke contraction of tracheal tissue via activation of PAR-2-TRPV4-ATP-cysLT axis indicating the potential disease relevance of this signaling pathway.
[European Respiratory Journal]

Full Article

Distinctive Roles of Abi1 in Regulating Actin-Associated Proteinsd during Human Smooth Muscle Cell Migration

Abelson interactor 1 (Abi1) knockdown by shRNA reduced human airway smooth muscle cell migration, which was restored by Abi1 rescue. Abi1 localized at the tip of lamellipodia and its protrusion coordinated with F-actin at the leading cell edge of live cells.
[Scientific Reports]

Full Article

Cytokine Regulation of Apoptosis-Induced Apoptosis and Apoptosis-Induced Cell Proliferation in Vascular Smooth Muscle Cells

Vascular smooth muscle cells (VSMCs) undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 and granulocyte-macrophage colony stimulating factor, leading to their secretion.
[Apoptosis]

Full Article

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REVIEWS

Exercise Adaptations: Molecular Mechanisms and Potential Targets for Therapeutic Benefit

The authors provide an overview of the beneficial adaptive responses to exercise and detail the molecular mechanisms involved. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach.
[Nature Reviews Endocrinology]

Abstract

INDUSTRY AND POLICY NEWS

Sarepta Therapeutics Signs Agreement with Hansa Biopharma for Imlifidase

Sarepta Therapeutics, Inc. announced an agreement with Hansa Biopharma, the leader in immunomodulatory enzyme technology for rare Immunoglobulin G mediated diseases, for imlifidase.
[Sarepta Therapeutics]


Press Release

Initiative Recruits Scientist-Volunteers to Aid COVID-19 Research

In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease.
[The Scientist]

Editorial

FEATURED EVENT

2020 Parenteral Drug Association (PDA) Virtual Pharmaceutical Manufacturing Data Science Workshop

July 13 – July 16
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoc Position – Cardiovascular Research

Albert Einstein College of Medicine – Bronx, New York, United States

PhD Student – Musculoskeletal Diseases

University Hospital of Muenster – Muenster, Germany

Postdoctoral Researcher/Surgery – Muscle Fibrosis

The University of Texas Southwestern Medical Center – Dallas, Texas, United States

Postdoctoral Fellow – Aging Muscle

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

Assistant Specialist – Cardiovascular Medicine

University of California, Davis – Davis, California, United States

Postdoctoral Position – Muscle Function

Spanish National Center for Cardiovascular Research – Madrid, Spain

> See All Jobs

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